KMID : 1141920210370040259
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Annals of Coloproctology 2021 Volume.37 No. 4 p.259 ~ p.265
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Prognostic Factors Affecting Disease-Free Survival and Overall Survival in T4 Colon Cancer
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Eom Tae-Yeong
Lee Yu-Jin Kim Jung-Bin Park In-Seok Gwak Geum-Hee Cho Hyun-Jin Yang Keun-Ho Kim Ki-Whan Bae Byung-Noe
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Abstract
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Purpose: It is known that as the T stage of a carcinoma progresses, the prognosis becomes poorer. However, there are few studies about factors that affect the prognosis of T4 advanced colon cancer. This study aimed to identify the prognostic factors associated with disease-free survival (DFS) and overall survival (OS) in T4 colon cancer.
Methods: Patients diagnosed with stage T4 on histopathology after undergoing curative surgery for colon cancer between March 2009 and March 2018 were retrospectively analyzed for factors related to postoperative survival. Primary outcomes were DFS and OS.
Results: Eighty-two patients were included in the study. DFS and OS of the pathologic (p) T4b group were not inferior to that of the pT4a group. Multivariate analysis showed that differentiation (hazard ratio [HR], 4.994; P = 0.005), and laparoscopic surgery (HR, 0.323; P = 0.008) were significant prognostic factors for DFS, while differentiation (HR, 7.904; P ¡Â 0.001) and chemotherapy (HR, 0.344; P = 0.038) were significant prognostic factors for OS.
Conclusion: Tumor differentiation, laparoscopic surgery, and adjuvant chemotherapy were found to be significant prognostic factors in patients with T4 colon cancer. Adjuvant chemotherapy and curative resections by laparoscopy might improve the prognosis in these patients.
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KEYWORD
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Colorectal neoplasms, Prognosis, Laparoscopy, Adjuvant chemotherapy
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